rst3

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About rst3

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    Bass, year-round. Tuna commercially
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    Professional sh¡tposter

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  1. Maybe in your town. ....but Brookline??? Not a chance. Town just passed new restrictions that mandate masking for pets. And during sex. And for corpses at wakes. Brookline's gonna be masking until we're all worm food
  2. lol That's actually a pretty good one. In this post's honor, some more charts below. :). *** Indian Variant Update- A consensus is rapidly developing that B1617.2 is probably going to blow the doors off just about everything else, and become the dominant strain in most countries. > It's a pretty big development. Kind of a big deal. Its cousin, B1617.1, does have moderate immune escape properties.. but not the same speed of transmission. So it's likely to get left behind. India. "617" vs 117(UK) vs 351(SA) India. Breakdown of Three Main 617 Strains '.2' is obviously dominant India. 617.2 clears the deck United Kingdom. 617.2 beat down of slow poke variants Been poking around Nerdsville last few days, and early calculations from the nerds on transmissibility of B1617.2 range from 50% faster than B117, up to 100% faster. That's awfully, awfully spready. If B117 has an Ro of 3-3.5....617.2 might be clocking in near 5, 5 and change.. Possibly higher. Example of different transmission speeds through a fully vulnerable population with no immunity. Obviously, any coronavirus with an Ro of 5 is going to blow through a vulnerable population pretty quickly. Very catchy variant. Much more so than the original Wuhan strain. I genuinely hope we vaccinate enough to keep this thing in check, like we did with B117/UK. The LAST thing we need is to get all comfy over the summer and back to normal ..then this stupid Indian variant bites us in the ass next fall
  3. I only took a quick look at a few studies, so big grain of salt on this one.. but I think the takeaway for monoclonal antibody treatment is that most big name 'variants of interest'(VOIs) or 'variants of concern'(VOCs) generally have moderate resistance to the treatments. Doesn't mean mAbs are bunk or useless.. just that they're less effective on variants than against the original wild/Wuhan covid strain. Here's an example of a recent test of the new Indian variants against two of the monoclonal treatments: Variant pseudotype neutralization by Regeneron REGN10933 and REGN10987 mAbs. Monoclonal antibody therapy for COVID-19 has been shown to reduce disease symptoms and to reduce the number of patients requiring hospitalization [19]. However, the treatment is subject to becoming less effective in patients infected with a variant in which the antibody epitope on the spike protein is altered by mutation. To address this question, we tested the ability of the mAbs to neutralize the panel of variant spike protein pseudotyped viruses. The results showed that the neutralizing titers of REGN10933 for B.1.617 virus was decreased by about 20-fold, similar to that of the E484K variant (Fig. 3A, D). [...] Neutralizing titers of REGN10987 for viruses with the L452R and B.1.617 were decreased by about 3-fold (Fig. 3B, D). The neutralizing titer of the mixture of REGN10933 and REGN10987 was 4.7-fold decreased in neutralizing titer for virus with the B.1.617 spike while the neutralization of virus with the B.1.618 spike was unchanged (Fig. 3C, D)." Translation: "Both variants were partially resistant to REGN10933, one of the two monoclonal antibodies constituting the REGN-COV2 therapy and virus with the B.1.617 spike was partially resistant to REGN10987 as well, resulting in a 4.7-fold decrease in neutralizing titer for the antibody cocktail." *** fwiw, the same study looked at the new Indian variants and how they responded to mRNA vaccine-induced antibodies. Mild to ehhh... maybe almost moderate resistance. But still plenty of stopping power under the hood for immune system. The authors concluded mRNA vaccines are still expected to provide good protection against the Indian variants.
  4. I know virtually nothing about monoclonal antibody treatments. I think(??) some of the strains with moderate immune escape properties (ex- the E484K mutation) have been able to dodge the monoclonals somewhat, however.
  5. Had blues lazily finning on top as well for me a few mornings back. The schools were slow moving dark blobs and easily visible in the calm waters of dawn. They were not outwardly attacking bait, at least not with surface splashes and bait spraying. When the blobs moved within casting range, so long as my pencil hit within 40 feet of the blob it was immediately set upon.
  6. Fig'd I'd chime back in. Some new information to pass along. Here in the northeast infection rates continue to collapse. New Jersey -- which saw a sizable spring rebound thanks to more transmissible variants -- is now undergoing exponential decline, with a drop of 80% over the past two weeks NJ: Massachusetts: cases are down 50% from two weeks ago. > The combination of mass vaccination and seasonality has overcome the transmission speed of B117... ...and driven the effective reproduction number(Rt) back below 1.0. So cases are dropping very fast once again. Over the next two months, case numbers should continue to decline. Good chance they hit record lows by late July. Beyond that? Outlook is very positive, but may be a few bumps in road this fall (see below) *** Indian variant B.1.617.2 appears to be the new transmission speed champ on the world stage. > UK variant B117 has been dethroned. Sorry Limeys. Very early* analysis suggests the Indian variant may transmit up to 50% faster than B117. And since B117 itself spreads 60% faster than original Wuhan C19...the new Indian bug flat out moves. Q: <Guy napping on hammock, raises head> "HEY! I'm vaccinated. Should I worry about the new Indian variant??" A: Nope. It does not carry significant immune escape properties. Vaccines have crushed it in early studies. Go back to sleep. Analysis showing Indian variant starting to outcompete B117. This phenomenon is most obvious in the UK portion of the graphs below: The above graphs also include the South African B1351 variant, which is the most immune resistant of all strains worldwide. It's still bumbling along at very low levels, mainly because other variants with faster transmission speed outcompete B1351's moderate immune escape properties. The UKs highly successful vaccination program has driven cases down to a low level. ..But cases are growing again in areas where B1617 is setting up shop. Its faster transmission speed changes the calculation for effective reproduction number(Rt), so areas that were below 1.0 with B117.. suddenly are back above 1.0 with B1617. However, the most highly vaccinated age groups (oldest cohort) are not showing a bounce. This means 75%+* vaccinated (*or whatever % age 60+ is in the UK) is enough to keep Rt for B1617 under 1.0 Also: the Bolton, UK outbreak developed (and remains concentrated in) in an area with the lowest vaccination rates. (At least for over 40s) Is there a decent chance that B1617 becomes a dominant player here in the US, over the next 2-4 months? Sure. It may slowly become established and widespread in coverage, even though overall covid case numbers nationwide should remain very low. States that could run into problems with this strain next fall? The Deep South. The vaccination rate in the South is roughly half of Massachusetts and the rest of New England. Looking ahead to next fall: I would not be surprised to see moderate outbreaks reccur with B1617 in the South. In fact, Alabama -- with its meager 35% 1st dose vaccination rate -- is one of only two states nationwide whose caseload is currently growing(AL up 90% in last two weeks). And that's just with B117. Unlikely to see much if any growth with B1617 in New England. By mid-fall, immunity here will probably be 75%+. Just from vaccination. Nevermind the ~33%(national number) who've already had covid and have natural immunity. The combined total immunity here in New England should be enough to overcome the faster transmission speed of B1617. And that will be that. *** > But if you're already vaccinated? then none of this variant crap even matters. B117? > Zzzzzz B1617?? > Zzzzzzzzz B-52s??? > Zzz--- ok fine. I'll get up for Rock Lobster *** If you're not vaccinated? Well, hopefully that works out for you. And I say that with all sincerity. I may disagree with your choice, but I'd be a sicko if I didn't feel bad about people getting sick...Or worse. Containment measures are now ending, so we're quickly heading back to normal social interaction. Thank the lord. But that also means those who aren't vaccinated will be back socially mixing.. and more easily reached by the virus. Even if it is squashed to a low level of circulation in our communities. I heard one doctor say, if you haven't had covid already and choose not to get vaccinated, then in all likelihood you'll pick up the virus at some point. > Ehhh..maybe, maybe not. But if you don't contract covid over the next few years? I'd say that has much more to do with your fellow citizens getting vaccinated and breaking the back of the virus in the US, than it does about your ability to dodge it.
  7. Decent bite overnight. 20-28"s, with most around 25. Yellow SS Needle in std weight got the most attention. Best fish on 9" pink megastrike. Interestingly, that low slot was bursting at the seams with eggs. Either that or she just swallowed 3 bunker. I assume it was a failed spawn attempt, and she'll either abort the useless deadstock or just re-absorb the eggs. Not sure what they usually do. After parking and feeding at one spot for 2hrs, the school moved off in one quick go, midtide. Dead after that, except had a ginormous needlefish attack my mag darter. Thing was like 16..18", easy. Didn't know they were around in chilly spring water. At dawn, some nice blues moved within range. Average probably 6lbs, but a few made a run at 9. Bait: 2" sand eels. Unknown bait: some smallish fish or squid was on the sand eels, and the blues were eating that
  8. Skinner has a video of this. Bass choked to death trying to swallow another bass. > at t= 12m 25s https://youtu.be/M2mWD1VWA5s&t=12m25s
  9. Test text. Re: Error 403
  10. @TimS My PMs haven't been able to be sent the last 48hrs. I get an error msg each time I try to send a PM. The content gets restored, but nothing will send. On Android mobile. Error:
  11. Here's a look at nitrogen deficiency in tomatoes. Older leaves go first. Nitrogen Deficiency progression->123 Some of your plants are still very dark green, so no lack of N there. Other deficiencies didn't really match that well, or at all, to what you posted. My guess is nitrogen.
  12. Soil temps still very chilly across SNE. Low 50s. Supposedly the weather pattern may shift to a little warmer stuff in a week or so. Which should help.
  13. I'm no tomato doctor, but I'd vote for nutrient deficiency. Probably several, so the mix of symptoms on the leaves may not be easily diagnosed by trying to compare to pictures of tomatoes with specific deficiencies. Might want to try a water soluble chem fertilizer which is able to be absorbed right away. Probably won't reverse the damage that's already showing, but should help the plants return to healthy growth. I've had issues in the past with plants running out of nutrients in small containers without supplemental fertilization. So my guess is that it's time to give your tomatoes some food. Also, your planters really look great. I'm thinking the soil in them will have warmed much more than a bed on the ground, so after the stretch of chilly nights this week, maybe consider poppin your starts in
  14. One thing I've found is that peppers seem to do very well when planting oversize, bigger seedlings/sm plants that have larger root systems vs rinky dink, scrony pepper seedlings with small root balls. At least the ones I've grown.. bigger plants root in quicker and get going fast, while smaller plants sometimes can take awhile to stick and grow. I haven't used 1G containers, maybe 6" pots. Something like that. Never had peppers large enough to fill out a 1G with roots before transplanting time arrived. Tomatoes: if they're big and have already started flowering, I pinch the flowers off to prevent early fruit set. When I didn't do that: I had transplants that spent all their limited energy developing a tomato or two the 1st month or so and lagged well behind the starts that went in small and didn't set fruit. Only upside is, if you have lots of space and plants .. these 1 or 2 tomato transplants ripen their first fruit super early. So you have a few to eat before any others ripen. These plants do eventually grow out and set a wave of later tomatoes, but they never reach their full potential size and yield.
  15. Early season I don't leave home without my tried and trusty zoom fluke. Both 5 and 7". Works everywhere. Herring runs, out front, parking lots, etc. Mag darter in there too.